Renal Biopsy Case History
June, 1995
Clinical Summary
A 40 year old Caucasian male developed edema and was found to have the nephrotic syndrome.
The patient gave a history of abdominal pain ("spastic colon") and a poorly defined peripheral
neuropathy. Physical examination was unremarkable except for pedal edema. Blood pressure
was normal and he weighed 160 lbs. Urinalysis demonstrated pH 5.0, SG 1.015, proteinuria and
3+ hematuria but no RBC casts. Urine protein measurement revealed 3.4 g/24 hrs. Additional
data included serum creatinine 1.8 mg/dl, BUN 22 mg/dl, albumin 2.6 g/dl, cholesterol 207 mg/dl,
positive anti-nuclear antibody assay at a titer of 1:80, C3 149, C4 30, CH50 65, no M-spike on
serum or urine protein electrophoresis, and negative hepatitis serology. A renal biopsy was
performed to determine the diagnosis and prognosis, and to direct management of the renal
dysfunction.
Micrographs
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yield good images of the pathology of the case. Each slide has a pathologic
description associated with the picture.
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Last Update -- June 9, 1995